| Game # | Date | Time | Opponent | Venue | Score | Result | Streak |
| Sep 12 2021 | 5:30 PM | Hamilton Hawks | Appleby Ice Centre-Rink 2 | 2-1 | W | W1 |
| Sep 19 2021 | 8:30 PM | North Halton Twisters | Appleby Ice Centre-Rink 3 | 1-3 | L | L1 |
| Sep 25 2021 | 7:15 PM | North Halton Twisters | Mold-Masters Sportsplex | 0-1 | L | L2 |
| Sep 26 2021 | 6:00 PM | Ancaster Avalanche | Mainway Arena-Rink 1 | 3-1 | W | W1 |
| Oct 02 2021 | 8:00 PM | Mississauga Hurricanes | Appleby Ice Centre-Rink 2 | 2-5 | L | L1 |
| Oct 06 2021 | 8:00 PM | Oakville Hornets | Joshua's Creek Arenas | 2-0 | W | W1 |
| Oct 09 2021 | 12:00 PM | Hamilton Hawks | Inch Park Arena | 3-3 | T | T1 |
| Oct 12 2021 | 9:00 PM | Ancaster Avalanche | Morgan Firestone Arena (Ancaster Community Centre) | 6-2 | W | W1 |
| Oct 16 2021 | 6:00 PM | Oakville Hornets | Appleby Ice Centre-Rink 2 | 2-2 | T | T1 |
| Oct 22-Oct 24 | Oshawa Lady General Fall Classic Tournament (2122012) | Oshawa, Ontario |
| 198 | Oct 22 2021 | 3:15 PM | Whitby Wolves | Delpark Homes Centre, Pad 4 | 1-1 | T | T2 |
| 200 | Oct 22 2021 | 9:00 PM | Mississauga Hurricanes | Delpark Homes Centre, Pad 4 | 2-1 | W | W1 |
| 204 | Oct 23 2021 | 10:30 AM | Gloucester Cumberland Stars | Canlan Sports, Pad 2 | 1-3 | L | L1 |
| 209 | Oct 23 2021 | 3:15 PM | Bluewater Hawks | Canlan Sports, Pad 1 | 3-2 | W | W1 |
| 241 | Oct 24 2021 | 9:30 AM | Whitby Wolves | Delpark Homes Centre, Pad 4 | 0-1 | L | L1 |
| Oct 31 2021 | 2:30 PM | St. Catharines Brock JR Badgers | Seymour-Hannah Sports & Entertainment Center (Sportsplex 4) | 5-4 | W | W1 |
| Nov 02 2021 | 7:00 PM | Flamborough Falcons | Mainway Arena-Rink 1 | 1-4 | L | L1 |
| Nov 05-Nov 07 | St. Catharines Brock Jr Badgers Rep Tournament (2122021) | St. Catharines, Ontario |
| 108 | Nov 05 2021 | 4:00 PM | Lindsay Lynx | Garden City Arena, Jack Gatecliff Rink, | 2-0 | W | W1 |
| 110 | Nov 05 2021 | 8:30 PM | Durham West Lightning | Bill Burgoyne Memorial Arena | 2-2 | T | T1 |
| 112 | Nov 06 2021 | 9:00 AM | St. Catharines Brock JR Badgers | Seymour-Hannah Sports & Entertainment Center (Sportsplex 4) | 0-0 | T | T2 |
| 113 | Nov 06 2021 | 1:45 PM | Belmont Blazers | Seymour-Hannah Sports & Entertainment Center (Sportsplex 4) | 1-1 | T | T3 |
| Nov 13 2021 | 4:00 PM | Stoney Creek Sabres | Gateway Ice Center | 1-1 | T | T4 |
| Nov 14 2021 | 12:00 PM | U15 AA (Ken Butler) | Central Arena | 3-5 | L | L1 |
| Nov 20 2021 | 6:00 PM | St. Catharines Brock JR Badgers | Appleby Ice Centre-Rink 2 | 5-3 | W | W1 |
| Nov 21 2021 | 2:00 PM | Flamborough Falcons | Harry Howell Arena (formerly North Wentworth Arena) | 0-6 | L | L1 |
| Nov 24 2021 | 8:30 PM | Stoney Creek Sabres | Saltfleet Arena (Fruitland Community Centre) | 2-1 | W | W1 |
| Nov 27 2021 | 8:00 PM | Hamilton Hawks | Mainway Arena-Rink 2 | 3-0 | W | W2 |
| Nov 28 2021 | 3:00 PM | Oakville Hornets | Joshua's Creek Arenas | 0-1 | L | L1 |
| Dec 04 2021 | 12:00 PM | Hamilton Hawks | Inch Park Arena | 1-3 | L | L2 |
| Dec 07 2021 | 8:00 PM | Oakville Hornets | Mainway Arena-Rink 2 | 2-4 | L | L3 |
| Dec 11 2021 | 8:00 PM | Ancaster Avalanche | Mainway Arena-Rink 2 | 3-2 | W | W1 |
| Dec 14 2021 | 7:00 PM | Flamborough Falcons | Mainway Arena-Rink 1 | | | |
| Jan 08 2022 | 3:00 PM | St. Catharines Brock JR Badgers | Appleby Ice Centre-Rink 2 | | | |
| Jan 09 2022 | 3:00 PM | Oakville Hornets | Joshua's Creek Arenas | | | |
| Jan 11 2022 | 9:00 PM | Ancaster Avalanche | Morgan Firestone Arena (Ancaster Community Centre) | | | |
| Jan 15 2022 | 12:00 PM | Hamilton Hawks | Inch Park Arena | | | |
| Jan 16 2022 | 11:00 AM | Stoney Creek Sabres | Mainway Arena-Rink 1 | | | |
| Jan 29 2022 | 7:30 PM | Ancaster Avalanche | Appleby Ice Centre-Rink 2 | | | |
| Feb 01 2022 | 6:30 PM | Stoney Creek Sabres | Mainway Arena-Rink 2 | 4-7 | L | L1 |
| Feb 04 2022 | 8:30 PM | Ancaster Avalanche | Morgan Firestone Arena (Ancaster Community Centre) | 2-5 | L | L2 |
| Feb 06 2022 | 12:00 PM | Hamilton Hawks | Central Arena | 4-5 | L | L3 |
| Feb 08 2022 | 6:30 PM | Flamborough Falcons | Mainway Arena-Rink 2 | 1-2 | L | L4 |
| OWOak1252Home | Feb 12 2022 | 3:30 PM | Oakville Hornets | Appleby Ice Centre-Rink 2 | 1-1 | T | T1 |
| Feb 13 2022 | 2:00 PM | Flamborough Falcons | Harry Howell Arena (formerly North Wentworth Arena) | 0-6 | L | L1 |
| Feb 15 2022 | 7:00 PM | Stoney Creek Sabres | Mainway Arena-Rink 1 | 1-1 | T | T1 |
| Feb 18 2022 | 9:00 PM | Stoney Creek Sabres | Gateway Ice Center | 3-0 | W | W1 |
| OWMiss5886Away | Feb 19 2022 | 11:45 AM | Mississauga Hurricanes | Iceland Sports Complex | 3-1 | W | W2 |
| OWMiss5881Home | Feb 20 2022 | 2:30 PM | Mississauga Hurricanes | Central Arena | 2-2 | T | T1 |
| Feb 25-Feb 27 | Brantford 40th Annual Walter Gretzky Tournament (2122003) | Brantford, Ontario |
| 51 | Feb 25 2022 | 2:00 PM | Lindsay Lynx | Brantford and District Civic Centre | 4-4 | T | T2 |
| 91 | Feb 25 2022 | 10:00 PM | Cambridge Roadrunners | Gretzky Sport Complex (Brantford), Rink #1 | 3-3 | T | T3 |
| 156 | Feb 26 2022 | 5:30 PM | Brantford Ice Cats | Gretzky Sport Complex (Brantford), Rink #1 | 4-1 | W | W1 |
| 184 | Feb 26 2022 | 9:45 PM | North York Storm | Gretzky Sport Complex (Brantford), Rink #4 | 1-0 | W | W2 |
| 192 | Feb 27 2022 | 9:45 AM | Ancaster Avalanche | Gretzky Sport Complex (Brantford), Rink #3 | 2-3 | L | L1 |
| Mar 03 2022 | 7:00 PM | Hamilton Hawks | Inch Park Arena | 1-1 | T | T1 |
| Mar 05 2022 | 8:00 PM | Ancaster Avalanche | Appleby Ice Centre-Rink 2 | 1-2 | L | L1 |
| Mar 06 2022 | 5:45 PM | St. Catharines Brock JR Badgers | Seymour-Hannah Sports & Entertainment Center (Sportsplex 4) | 3-2 | W | W1 |
| OWOak1259Away | Mar 09 2022 | 8:30 PM | Oakville Hornets | Joshua's Creek Arenas | 0-3 | L | L1 |
| Mar 12 2022 | 6:30 PM | St. Catharines Brock JR Badgers | Appleby Ice Centre-Rink 2 | | | |
| Mar 19 2022 | 8:30 PM | Ancaster Avalanche | Morgan Firestone Arena (Ancaster Community Centre) | 0-4 | L | L2 |
| Mar 26 2022 | 6:30 PM | Etobicoke Dolphins | Appleby Ice Centre-Rink 2 | 1-3 | L | L3 |
| Mar 29 2022 | 6:30 PM | Brantford Ice Cats | Mainway Arena-Rink 2 | 3-0 | W | W1 |
| Apr 02 2022 | 5:45 PM | Etobicoke Dolphins | Ford Performance Centre | 2-4 | L | L1 |
| Apr 07 2022 | 6:30 PM | Brantford Ice Cats | Gretzky Sport Complex | 4-2 | W | W1 |
| Apr 15-Apr 17 | Brampton Canadettes Easter Tournament (2122046) | Brampton, Ontario |
| 575 | Apr 15 2022 | 10:45 AM | Mississauga Hurricanes #5886 | Century Gardens Arena (Century Gardens Recreation Centre), Rink #2 (Brampton) | 2-4 | L | L1 |
| 576 | Apr 15 2022 | 2:00 PM | Cambridge Roadrunners #2200 | CAA Centre (Brampton), Spectator Rink | 1-7 | L | L2 |
| 578 | Apr 16 2022 | 2:45 PM | Etobicoke Dolphins #419 | Century Gardens Arena (Century Gardens Recreation Centre), Rink #2 (Brampton) | 5-1 | W | W1 |
| 587 | Apr 17 2022 | 12:45 PM | Mississauga Hurricanes #5881 | Century Gardens Arena (Century Gardens Recreation Centre), Rink 2, (Brampton) | | | |